Phosphoinositide Signal Transduction Pathway and Osteosarcoma Metastases

: Metastasis spreading confers a worse prognosis to the clinical outcome among patients suffering from osteosarcoma, most common primary bone tumor in childhood and adolescence. The detection of molecules involved metastasis might contribute understanding dissemination mechanisms, thereby opening way novel therapeutic strategies. Ezrin-radixin-moesin (ERM) family proteins are activated after interacting with belonging phosphoinositide signal transduction pathway. phosphatydil inositol (4,5) bisphosphate (PIP2), crucial molecule PI pathway, stabilizes ERM or more efficient receptor binding. PIP2 levels pathway critical element for regulating several cell events. regulated using enzymes, including PI-specific Phospholipase C family. A decrease induces dissociation protein membrane. In this regard, PI-PLC enzymes regulate event. paper, role osteosarcoma metastases is discussed.